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Systemic Radiotherapy with Monoclonal Antibodies: Options and Problems by Marie-

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Specificaties

Objectstaat
Nieuw: Een nieuw, ongelezen en ongebruikt boek in perfecte staat waarin geen bladzijden ontbreken of ...
ISBN-13
9783642799549
Book Title
Systemic Radiotherapy with Monoclonal Antibodies
ISBN
9783642799549
Subject Area
Medical
Publication Name
Systemic Radiotherapy with Monoclonal Antibodies : Options and Problems
Item Length
9.3 in
Publisher
Springer Berlin / Heidelberg
Subject
Immunology, Oncology, Radiology, Radiotherapy & Nuclear Medicine
Publication Year
2011
Series
Recent Results in Cancer Research Ser.
Type
Textbook
Format
Trade Paperback
Language
English
Item Height
0.2 in
Author
Heiner Bihl
Item Width
6.1 in
Item Weight
11.6 Oz
Number of Pages
IX, 198 Pages

Over dit product

Product Information

Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio­ labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.

Product Identifiers

Publisher
Springer Berlin / Heidelberg
ISBN-10
364279954x
ISBN-13
9783642799549
eBay Product ID (ePID)
23038719967

Product Key Features

Author
Heiner Bihl
Publication Name
Systemic Radiotherapy with Monoclonal Antibodies : Options and Problems
Format
Trade Paperback
Language
English
Subject
Immunology, Oncology, Radiology, Radiotherapy & Nuclear Medicine
Publication Year
2011
Series
Recent Results in Cancer Research Ser.
Type
Textbook
Subject Area
Medical
Number of Pages
IX, 198 Pages

Dimensions

Item Length
9.3 in
Item Height
0.2 in
Item Width
6.1 in
Item Weight
11.6 Oz

Additional Product Features

Intended Audience
Scholarly & Professional
Series Volume Number
141
Number of Volumes
1 Vol.
Lc Classification Number
Rc254-282
Reviews
"a timely and deliberately provocative new impetus to this long overdue discussion of promising, selective cancer treatment." Jnl. of the National Cancer Institute
Table of Content
Monoclonal Antibodies in Tumor Therapy.- Experimental Radioimmunotherapy: Biological Effectiveness and Comparison with External Beam Radiation.- Higher Efficiency of 131I-Labeled Anti-Carcinoembryonic Antigen-Monoclonal Antibody (Fab?)2 as Compared to Intact Antibodies in Radioimmunotherapy of Established Human Colon Carcinoma Grafted in Nude Mice.- Problems and Advances in the Dosimetry of Radionuclide Targeted Therapy.- Minimal Residual Disease: a Target for Radioimmunotherapy with 131I-Labeled Monocloncal Antibodies? Some Dosimetric Considerations.- Optimal Therapeutic Strategies for Radioimmunotherapy.- Two Approaches for Enhancing Radioimmunotherapy: ? Emitters and Hyperthermia.- Can Preirradiation Enhance Tumor Uptake of Radiolabeled Pharmaceuticals? Experimental Data in a Mouse Neuroblastoma Xenograft System.- The Use of Radioimmunotherapy in Combination with Bioreductive Agents.- Treatment of Diffuse Leptomeningeal Malignancy by Intrathecal Injection of 131I-Radioimmunoconjugates.- The Treatment of Patients with Recurrent Malignant Gliomas with Intratumoral Radioimmunoconjugates.- High Dose Radioimmunotherapy in Malignant Lymphoma.- The Use of Epidermal Growth Factor Receptor-425 Monoclonal Antibodies Radiolabeled with Iodine-125 in the Adjuvant Treatment of Patients with High Grade Gliomas of the Brain.
Copyright Date
1996
Illustrated
Yes

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